BMP/TGF-BETA/ACTIVIN/GDF SIGNALING AND PHARMACOLOGIC MODULATION
- Yu PB, Beppu H, Kawai N, Li E, Bloch KD. Bone Morphogenetic Protein (BMP) Type II Receptor Deletion Reveals BMP Ligand-Specific Gain of Signaling in Pulmonary Artery Smooth Muscle Cells. J Biol Chem. 2005 Jul 1;280(26):24443-50. PDF
- Yu PB*, Hong CC*, Sachidanandan C*, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT. Dorsomorphin Inhibits BMP Signals Required for Embryogenesis and Iron Metabolism. Nat Chem Biol. 2008 Jan; 4(1): 33-41. *equal contribution. PDF
- Bagarova J, Vonner AJ, Armstrong KA, Böergermann J, Lai CS, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB. Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation. Molecular and Cellular Biology. 2013 Jun; 33(12): 2413-24. PDF
- Wrighton KH, Lin X, Yu PB, Feng XH. TGF-b Can Stimulate Smad1 Phosphorylation Independently of BMP Receptors. Journal of Biological Chemistry. 2009 Apr; 284(15): 9755-63. PDF
- Mohedas AH, Xing X, Armstrong KA, Bullock AN, Cuny GD, Yu PB. Development of a Highly Selective Inhibitor of the BMP Type I Receptor Kinase ALK2. ACS Chemical Biology. 2013 Apr; 8(6): 1291-1302. PDF
- Hoeman CM, Cordero FJ, Hu G, Misuraca K, Romero MM, Cardona HJ, Nazarian J, Hashizume R, McLendon R, Yu PB, Procissi D, Gadd S, Becher OJ. ACVR1 R206H Cooperates With H3.1K27M in Promoting Diffuse Intrinsic Pontine Glioma Pathogenesis. Nature Communications. 2019 Mar 4;10(1):1023. PDF
- Dinter T, Bocobo GA, Yu PB. Pharmacologic Strategies for Assaying BMP Signaling Function. Methods Mol Biol. 2019 Aug;1891:221-33. PDF
- Yin H, Kalra L, Lai Z, Guimaro MC, Aber, L, Warner BM, Michael DG, Zhang N, Cabrera-Perez J, Karim A, Swaim B, Afione S, Voigt A, Nguyen CQ, Yu PB, Bloch DB, Chiorini JA. Inhibition of Bone Morphogenetic Protein 6 Receptors Ameliorates Sjögren’s Syndrome in Mice. Sci Rep. 2020 Feb 19;10(1):2967. PDF
CARDIOPULMONARY PHYSIOLOGY AND PULMONARY ARTERIAL HYPERTENSION (PAH)
- Long L, Ormiston ML, Yang X, Southwood M, Gräf S, Machado RJ, Muelle M, Kinzel B, Yung LM, Wilkinson JM, Moore SD, Drake KM, Aldred MA, Yu PB, Upton PD, Morrell NW. Selective Enhancement of Endothelial BMPR-II With BMP9 Reverses Pulmonary Arterial Hypertension. Nature Medicine, 2015 Jul;21(7):777-85. PDF
- Yung LM, Nikolic I, Paskin-Flerlage SD, Pearsall RS, Kumar R, Yu PB. A Selective TGFβ Ligand Trap Attenuates Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 Nov 1;194(9):1140-51. *Recommended as “Exceptional” in F1000 Prime. PDF
- Nikolic I, Yung LM, Yang P, Malhotra R, Paskin-Flerlage SD, Dinter, T, Bocobo, GA, Tumelty KE, Faugno AJ, Troncone L, McNeil ME, Huang X, Coser KR, Lai CSC, Upton PD, Goumans MJ, Zamanian RT, Elliott CG, Lee A, Zheng W, Berasi SP, Huard C, Morrell NW, Chung RT, Chabnnick RW, Roberts KE, Yu PB. Bone Morphogenetic Protein 9 is a Mechanistic Biomarker of Portopulmonary Hypertension. Am J Respir Crit Care Med. 2019 Apr 1;199(7):891-902. Recognized by AHA as one of the “Top Heart Disease and Stroke Research Advances in 2019”. https://newsroom.heart.org/news/top-heart-disease-and-stroke-research-advances-in-2019 PDF
- Hodgson J, Swietlik EM, Salmon RM, Hadinnapola C, Nikolic I, Wharton J, Guo J, Liley J, Haimel M, Bleda M, Southgate L, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani HA, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, Lawrie A, MacKenzie Ross RV, Moledina S, Montani D, Olschewski A, Olschewski H, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Suntharalingam J, Toshner MR, Trembath RC, Vonk Noordegraaf A, Wort SJ, Wilkins MR, Yu PB, Li W, Gräf S, Upton PD, Morrell NW. Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2020 Mar 1;201(5):575-85. PDF
- Yung LM, Yang P, Joshi S, Augur ZM, Kim SSJ, Bocobo GA, Dinter T, Troncone L, Chen PS, McNeil ME, Southwood M, Poli de Frias S, Knopf J, Rosas IO, Sako D, Pearsall RS, Quisel JD, Li G, Kumar R,Yu PB. ACTRIIA-Fc Rebalances Activin/GDF Versus BMP Signaling in Pulmonary Hypertension. Sci Transl Med. 2020 May 13;12(543). PDF
BONE BIOLOGY, HETEROTOPIC OSSIFICATION AND FIBRODYSPLASIA OSSIFICANS PROGRESSIVA (FOP)
- Yu PB, Donna Y. Deng, Carol S. Lai, Charles C. Hong, Gregory D. Cuny, Mary L. Bouxsein, Deborah W. Hong, Patrick M. McManus, Takenobu Katagiri, Chetana Sachidanandan, Nobuhiro Kamiya, Tomokazu Fukuda, Yuji Mishina, Randall T. Peterson, and Kenneth D. Bloch. BMP Type I Receptor Inhibition Prevents Ectopic Ossification in a Mouse Model of Fibrodysplasia Ossificans Progressiva. Nature Medicine. 2008; 14(12): 1363-9. PDF
- Hatsell SJ, Idone V, Alessi-Wolken DM, Huang L, Kim HJ, Wang L, Wen XL, Nannuru KC, Jimenez J, Xie L, Makhoul G, Chernomorsky R, D’Ambrosio D, Corpina RA, Schoenherr C, Feeley K, Yu PB, Yancopoulos GD, Murphy AJ, Economides AN. ACVR1R206H Receptor Mutation Causes Fibrodysplasia Ossificans Progressiva by Gaining Responsiveness to Activin A. Science Translational Medicine, 2015 Sep; 7(303): 303ra137. *Accompanying Editorial in Science. PDF
- Dey D, Bagarova J, Hatsell SJ, Armstrong K, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EMW, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB. Two Tissue-Resident Progenitor Lineages Drive Distinct Phenotypes of Heterotopic Ossification. Science Translational Medicine. 2016 Nov 23;8(366):366ra163. PDF
- Kim JM, Yang YS, Park KH, Ge XP, Xu R, Li N, Song MY, Chun HH, Bok SY, Charles JF, Fihl-Cochet O, Boldyreff B, Dinter D, Yu PB, Kon N, Gu W, Takarad T, Greenblatt MB, Shim JH. A novel RUNX2 Stabilization Pathway Mediates Physiologic and Pathologic Bone Formation. Nat Commun. 2020 May 8;11(1):2289. PDF
MOLECULAR IMAGING OF CARDIOPULMONARY DISEASE
- Yung LM, Yu PB. Room With a View: Towards Molecular Imaging of Pulmonary Vascular Remodeling. Circulation Cardiovascular Imaging. 2018 Aug;11(8): e008148. PDF
ANEMIA AND IRON HOMEOSTASIS
- Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, Peterson RT, Bloch KD*, Yu PB*. Inhibition of Bone Morphogenetic Protein Signaling Attenuates Anemia Associated With Inflammation. Blood. 2011 May; 117(18): 4915-23. *equal contribution. PDF
- Steinbicker AU, Bartnikas TB, Lohmeyer LK, Leyton P, Mayeur C, Kao SM, Pappas AE, Peterson RT, Bloch DB, Yu PB, Fleming MD, Bloch KD. Perturbation of Hepcidin Expression by BMP Type I Receptor Deletion Induces Iron Overload in Mice. Blood. 2011 Oct; 118(15): 4224-30. PDF
- Mayeur C, Lohmeyer LK, Leyton P, Kao SM, Pappas AE, Kolodziej SA, Spagnolli E, Yu B, Galdos RL, Yu PB, Peterson RT, Bloch DB, Bloch KD, Steinbicker AU. The Type I BMP Receptor, Alk3, is Required for the Induction of Hepatic Hepcidin Gene Expression by Interleukin-6. Blood. 2014 Apr 3;123(14):2261-8. PDF
VASCULAR CALCIFICATION
- Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD*, Yu PB*. Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Jan; 32(3): 613-22. *equal contribution. PDF
- Malhotra R, Burke MF, Martyn T, Shakartzi HR, Thayer TE, O’Rourke C, Li P, Derwall M, Spagnolli E, Kolodziej SA, Hoeft K, Mayeur C, Jiramongkolchai P, Kumar R, Buys ES, Yu PB, Bloch KD, Bloch DB. Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix GLA Protein Deficiency. PLoS One. 2015 Jan 20;10(1):e0117098. PDF
- Yung LM, Sánchez-Duffhues G, ten Dijke P, Yu PB. Bone Morphogenetic Protein 6 and Oxidized Low-Density Lipoprotein Synergistically Recruit Osteogenic Differentiation in Endothelial Cells. Cardiovascular Research, 2015 Nov 1;108(2):278-87. *Editors Choice. PDF
- O’Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R. Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation. J Vis Exp. 2016 May 31;(111):54017. PDF
- Yang P, Troncone L, Augur ZM, Kim SSJ, McNeil ME, Yu PB. The role of bone morphogenetic protein signaling in vascular calcification. Bone. 2020 Dec;141:115542. PDF